Количество страниц: 6 с.
A study was carried out to determine the dynamics of collagenase levels of the second subfamily (MMR-2, MMR-9) and their inhibitors (TIMP-1 and TIMP-2) in blood of patients with local cold injury (LCI). It was found out that in patients with LCI the level of MMR-2 and MMR-9 in serum increases with respect to the control group in the early period of cryodamage, and also the indices of the studied markers increase directly proportional to the volume of the affected tissues. The same dynamics was observed in the study of matrix metalloproteinase inhibitors parameters. On the basis of the obtained data and analysis of the linear regression equation a prognostic model was formed, which allows to suspect with high accuracy the level of tissue affection in the early terms of local cold injury
Значение матриксных металлопротеиназ их ингибиторов в течении раневого процесса при местной холодовой травме / М. И. Михайличенко, К. Г. Шаповалов, В. А. Мудров, О. С. Груздева // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 72-76. – DOI: 10.25789/YMJ.2020.70.22.
DOI: 10.25789/YMJ.2020.70.22
Количество страниц: 4 с.
The frequency of alleles and haplotypes of blood groups AB0, MN, Rhesus and Kell in the sample of indigenous population of Kyzyl city was studied in comparison with some Siberian populations belonging to other language groups. It is shown that Tuvinians of Kyzyl city are genetically close to Yakuts and southern Altaians, and the combination of Caucasian and Mongoloid genetic markers reflects their complex ethnic history
Особенности генофонда тувинского этноса на основе изучения антигенов групп крови в сравнительном аспекте / Л. Э. Табиханова, Л. П. Осипова, С. С. Ковалев [и другие] // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 84-87. – DOI: 10.25789/YMJ.2020.70.25.
DOI: 10.25789/YMJ.2020.70.25
Количество страниц: 6 с.
To study the prevalence of gastroesophageal reflux disease (GERD), erosive and ulcerative diseases of gastroduodenal zone and their association in schoolchildren from different regions of Siberia with hereditary predisposition to stomach pathology, schoolchildren from the Republic of Tyva, Buryatia and Evenkia were examined. The prevalence of GERD among schoolchildren in Tyva was higher than in Buryatia and Evenkia. The destructive process of stomach mucosa and duodemum was also higher in Tyva. In children with erosive ulcerative lesions of the gastroduodenal zone, comorbidity of the esophagus was also more frequently determined. The significant influence of family predisposition to stomach pathology on the prevalence of GERD, erosive- ulcer diseases of gastroduodenal zone, as well as their association in Siberian schoolchildren was established. At the same time, territorial features influence the severity of these processes
Поливанова, Т. В. Взаимосвязь семейной предрасположенности к патологии желудка с эрозивно-язвенными поражениями гастродуодальной зоны и ГЭРБ у школьников Сибири / Т. В. Поливанова, В. А. Вшивков // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 88-92. – DOI: 10.25789/YMJ.2020.70.26.
DOI: 10.25789/YMJ.2020.70.26
Количество страниц: 4 с.
We determined the level of brain neurotrophic factor BDNF in plasma of adolescents aged 12-17 with syncopal conditions. Lower BDNF levels in plasma were found in a large number of adolescents examined. Taking into account the significant role of BDNF in the modulation of neuroplastic processes, the revealed decrease in its level can probably be regarded as a metabolic marker of the risk of neurodegenerative processes appearance and presence in brain tissue of adolescents with recurrent syncope. This assumption can be confirmed by further studies. Conclusions: syncopal conditions in adolescents are associated with a lower content of brain neurotrophic factor BDNF. In adolescents with syncopal conditions, there are more individuals with slightly or significantly lower BDNF compared to the group without syncope
Ахмельдинова, Ю. Р. Уровень мозгового нейротрофического фактора BDNF у подростков с синкопальными состояния / Ю. Р. Ахмельдинова, Л. С. Эверт, Т. В. Потупчик // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 92-95. – DOI: 10.25789/YMJ.2020.70.27.
DOI: 10.25789/YMJ.2020.70.27
Количество страниц: 4 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Лекарствоведение. Фармакология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Гастроэнтерология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Лекарствоведение. Фармакология. Общая терапия,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Гастроэнтерология.
The pharmacological activity of the sum of phenolic compounds isolated from the multicomponent extract "Hexafeet", which has choleretic activity, and its role in the mechanism of action of this extract were studied. The positive effect of the sum of phenolic compounds on the cholate-forming, cholato-separation, antioxidant and membrane-stabilizing effect of "Hexafeet" extract in experiments on laboratory animals has been established
Ферубко, Е. В. Исследование роли фенольных соединений в механизме действия нового средства для профилактики и лечения заболеваний органов пищеварения / Е. В. Ферубко // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 96-98. – DOI: 10.25789/YMJ.2020.70.28.
DOI: 10.25789/YMJ.2020.70.28
Количество страниц: 4 с.
The literature review provides modern data on the genital microbiocenosis, describes the role of the most common microorganisms in the initialization of the inflammatory process. The integral role of opportunistic microorganisms is described in the development of inflammatory diseases of the pelvic organs.
Солтыс, П. А. Микробиом репродуктивного тракта женщины и воспалительные заболевания органов малого таза / П. А. Солтыс, М. С. Селихова // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 95-98. – DOI: 10.25789/YMJ.2020.69.23.
DOI: 10.25789/YMJ.2020.69.23
Количество страниц: 6 с.
Cardiohemodynamics and variability of heart rhythm at rest and at local cold influence in individuals with different initial types of vegetative regulation are studied. The obtained results indicate that young men with a predominance of parasympathetic orientation in the heart rhythm regulation demonstrate high stability of autonomic regulation to the presented cold test, which was manifested by the absence of statistically significant shifts in all studied cardiorhythm indicators and may indicate the cold resistance of this contingent
Аверьянова, И. В. Показатели сердечно-сосудистой системы и кардиоритма у юношей Магаданской области при локальном холодовом действии / И. В. Аверьянова // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 80-84. – DOI: 10.25789/YMJ.2020.69.19.
DOI: 10.25789/YMJ.2020.69.19
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Лекарствоведение. Фармакология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Онкология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Кардиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Кардиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Лекарствоведение. Фармакология. Общая терапия,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Онкология.
A controlled open randomized study of the parameters of biochemical and antioxidant status in ovarian cancer patients was conducted. It was established that the administration of chemotherapeutic drugs contributes to a reliable increase of plasma levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lipid hydroperoxides, diene conjugates, malondialdehyde. Analysis of the influence of chemotherapy on the activity of antioxidant system components also showed a decrease in the content of ceruloplasmine and vitamin E. Thus, the inclusion of antioxidants in the treatment scheme of ovarian cancer patients should be considered pathogenetically justified, clinically reasonable and promising
Результаты исследования параметров биохимического и антиоксидантного статуса у больных раком яичника в процессе биохимии / Д. А. Бондаренко, Д. В. Смирнов, Н. В. Симонова [и другие]. // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 38-42. – DOI: 10.25789/YMJ.2020.69.09.
DOI: 10.25789/YMJ.2020.69.09
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Психиатрия,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Онкология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Онкология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Психиатрия.
Female patients with histologically verified breast cancer, including newly diagnosed breast cancer and with a history of 3-17 years were under study. In the clinical picture of the examined patients, depressive, anxious-phobic and psycho-somatic disorders were identified, which significantly reduced their quality of life and adversely affected the prognosis and survival of patients. Conducting specialized pharmacotherapy with the use of antidepressants in combination with benzodiazepine drugs and hypnotics in breast cancer patients revealed high efficacy of the combination therapy
Шушпанова, О. В. Терапия больных раком молочной железы с тревожно-депрессивными расстройствами / О. В. Шушпанова, С. В. Иванов, Т. В. Шушпанова // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 34-38. – DOI: 10.25789/YMJ.2020.69.08.
DOI: 10.25789/YMJ.2020.69.07
Количество страниц: 4 с.
At present, there are five types of myocardial infarction, depending on the mechanism of disease development, which is consistent with the IV universal definition of myocardial infarction (MI). This article provides a clinical anatomical analysis of 90 cases of various types of MI. Diagnostic features and the incidence of myocardial infarction were evaluated from a clinical and pathological point of view
Мустафин, Т. И. Пути оптимизации морфологической диагностики различных типов миокарда / Т. И. Мустафин, С. В. Щекин, В. С. Щекин// Якутский медицинский журнал. — 2020. — N 1 (69). — С. 30-33. – DOI: 10.25789/YMJ.2020.69.07.
DOI: 10.25789/YMJ.2020.69.07