Количество страниц: 4 с.
Боякова, С. И. Народы Арктики: механизмы адаптации к экстремальной природной среде / С. И. Боякова // Наука и образование. – 2001. – N 2 (22). – С. 74-77.
Количество страниц: 4 с.
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология.
The article presents the results of the analysis of the literature data on the molecular genetic mechanisms of control and regulation of circadian rhythms that determine the chronotype of a person. It has been established that disturbance of circadian rhythms arising as a result of psychoemotional and physical stress expressed in degree and / or duration, can lead to a decrease in the body's resistance to stress factors with the subsequent development of maladjustment processes, which in turn can be a trigger mechanism for the onset of the development of such pathological conditions as diseases of the cardiovascular system, gastrointestinal tract, autoimmune, mental, neurodegenerative, oncological and other diseases. According to the results of numerous studies, the molecular genetic control of circadian rhythms consists of interacting positive and negative feedbacks of regulatory loops of clock genes, such as genes Bmal1, Clock, Per1, Per2, Per3, TIM, Npas2, Cry1 and Cry2, Csnk1d, Csnk1e, Rev-erbα, Rora, Bhlhe40, Bhlhe41, as well as genes FBXL3, FTO, MADD, CYP2A6, ARNTL, Mel1a, Mel1b and GPR50. The transcription factors encoded by these genes, enzymes, transporters, prohormones, signaling and other proteins are involved in regulation of daily frequency. Despite the fact that the main components of the molecular genetic mechanisms of circadian rhythms are already known, the issue of regulating their work remains relevant today. The results of studies carried out on different populations with respect to individual polymorphic variants of genes are not always unambiguous and require a more detailed study, since it is the result of the interaction of genes that can determine their phenotypic effect. Thus, understanding the molecular mechanisms and identifying genetic markers that cause disturbances in circadian rhythms is an important step in the development of methods aimed at preventing and correcting pathological conditions caused by maladjustment processes
Соловьева, Н. А. Генетические аспекты регуляции циркадных ритмов, влияющих на устойчивость к стрессу / Н. А. Соловьева, О. Н. Колосова // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 112-115.
DOI: 10.25789/YMJ.2020.72.27
Количество страниц: 6 с.
This article presents the comparative characteristics of the dynamics of indicators of physical development of young men. The study aims to carry out a comparative analysis of the dynamics of morphological and functional indicators of physical development and the functional state of male bodies at the youthful stage of ontogenesis. We have analyzed the results of the one-time study (1999 and 2019) of 1st-year students; in total, 760 young male students were examined in 1999, and 273 students in 2019 (aged 17-18). To reveal research results of physical development indicators, we have carried out a comprehensive study of somatoscopic, somatometric, and functional indicators of young men. Analysis of the morphological and functional indicators of men in Yakutia at the youthful stage of ontogenesis over time (20 years of difference). We take into account the individual typological characteristics of the organism, manifested at the structural and functional level (somatotype), and reflected in the main anatomical and anthropological indicators of the organism. This makes it possible to state the impact of external factors (environmental, social influences; a complex of genetic and cultural characteristics) on the indigenous people of the North
Сравнительная характеристика динамики морфофункциональных показателей физического развития мужчин молодого возраста / Д. К. Гармаева, С. П. Винокурова, Л. И. Аржакова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 61-65
DOI: 10.25789/YMJ.2020.72.16
Количество страниц: 4 с.
The immune system constantly responds to various environmental stimuli. The aim of the study was to investigate immune effects of short-term cold exposure taking into account ATP level in peripheral blood lymphocytes in healthy residents of the North. So, the total number of lymphocytes and their phenotypes, as well as the content of cytokines and the concentration of ATP in the lymphocytes were determined in 38 volunteers twice (before and after their short-term stay for 5 minutes in a cold chamber at t = -25°C). Cluster analysis revealed two statistically different groups. The first group with an initially higher ATP level in lymphocytes responded to hypothermia by lower ATP concentration with the unchanging total number of lymphocytes as well as by a decrease in predominantly CD16+ killer-cells. The other group reacted by an increase in ATP concentration with a decrease in the number of lymphocytes and by a pronounced decrease in CD4+ helper-cells and in CD71+ cells with a transferrin receptor. Also, the proinflammatory cytokines TNFa and IL-6 increased in the first group, while the second group showed a decrease in the level of lymphocyte-activating cytokine IL-1p. It can be assumed that the response to hypothermia in the first group is provided through the CIRP-NFkB-TNFa axis and leads to an increase in the risk of non-infectious inflammation. For the second group, a protective mechanism is triggered to restrain lymphocyte activity and the development of T-cell-mediated inflammation through regulation by means of T-effector and T-regulatory cells AMPK balance, autophagy, mitophagy and mitochondrial biogenesis. The study of the immune response to hypothermia is important for understanding the cellular mechanisms of adaptation as well as for the search of targets to correct the immune response
Зубаткина, О. В. Изменение иммунных показателей и уровня АТФ лимфоцитов периферической крови у северян при кратковременном холодовом воздействии на организм / О. В. Зубаткина, Л. К. Добродеева, С. Д. Круглов // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 90-93
DOI: 10.25789/YMJ.2020.72.22
Количество страниц: 6 с.
The aim of the study was to develop centile tables to assess basic parameters of the dynamic components of the postural balance in women 60-74 years old. Three groups of women aged 60-64 years, 65-69 years, and 70-74 years, with a total number of 186 people, were examined. Evaluation of main indicators of the postural balance was carried out using the computer stabilometric complex "Balance Manager". The presented standards will help to increase the information content of research and objective analysis of the results obtained, as well as to evaluate the effectiveness of the implementation of measures to maintain normal, safe walk or prevention of mobility restriction
Оценка параметров динамического компонента постурального баланса у женщин пожилого возраста / Т. П. Ширяева, А. В. Грибанов, Д. М. Федотов, О. А. Румянцева // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 27-31
DOI: 10.25789/YMJ.2020.72.07
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Гигиена. Санитария,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Гигиена. Санитария.
The limits and correlation of apoptosis and necrosis of neutrophil granulocytes in venous peripheral blood in apparently healthy people were studied. It was found that w contehen increasing the content of necrotic neutrophils AnV+/PI+, the concentration of apoptotic cells AnV+/PI-increases statistically to a large extent associated with the reduction of circulating neutrophils, monocytes, and t-helper cells. Thus, activation of neutrophil loss by necrosis can become a pathogenetic mechanism of cell membrane damage (nuclear, lysosomal, or cellular), as well as the formation of T-helper immunodeficiency
Соотношение уровня некроза и апоптоза нейтрофилов периферической крови у практически здоровых северян / О. А. Ставинская, Л. К. Добродеева, С. Н. Балашова, В. П. Патракеева // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 23-27
DOI: 10.25789/YMJ.2020.72.06
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Психиатрия,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Психиатрия.
The authors analyzed dietary intake of freestyle wrestlers depending on the season, taking into account the daily energy expenditure. The obtained data conclude that the daily food ration calorie does not reimburse the daily energy consumption of athletes. The chemical composition of nutrients in the daily diet of athletes quantitatively and qualitatively does not correspond to the standards recommended for freestyle wrestlers
Анализ фактического питания спортсменов-единоборцев в условиях Якутии / Л. И. Константинова, Е. И. Семёнова, А. В. Ефремова [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 68-73
DOI: 10.25789/YMJ.2020.69.16
Количество страниц: 6 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология.
The results of comparative study of chronic generalized periodontitis (CGP) of average severity in elderly and senile patients are reported. The development of CGP of medium severity in elderly and senile people is accompanied by activation of humoral immunity with excessive synthesis of all immunoglobulins in blood and saliva, the pressure of complementary activity is established, analysis of indicators of general and local immunity indicates differences between elderly and se-nile patients
Показатели врожденного и адаптивного иммунитета при хроническом генерализованном пародонтите у больных пожилого и старческого возраста / И. С. Пинелис, Ю. И. Пинелис, М. С. Малежик, И. Д. Ушницкий // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 63-68
DOI: 10.25789/YMJ.2020.69.15
Количество страниц: 4 с.
The study was conducted with aim to assess the effect of clinical and laboratory parameters and JAK2V617F mutation on the incidence of thrombotic complications in patients with classical Ph-negative chronic myeloproliferative diseases. JAK2V617F mutation was detected in patients with polycythemia vera, essential thrombocythemia and patients with primary myelofibrosis. Thrombotic complications were significantly more often observed in carriers of the JAK2V617F mutation and in patients with cardiovascular risk factors
Взаимосвязь носительства мутации JAK2V617F и частоты тромботических осложнений среди пациентов с классическими Ph-негативными хроническими миелопролиферативными заболеваниями / Т. Н. Александрова, И. И. Мулина, Х. А. Куртанов [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 21-23.
DOI: 10.25789/YMJ.2020.69.04
Количество страниц: 6 с.
Our investigation was influenced by the absence of common view on endovascular treatment tactics of patients with large and giant cerebral arteriovascular malformations. Using principles of staged AVM obliteration based on angioarchitectonics and modern technological advances, we managed to increase surgical efficacy by less number of stages and to increase good results in patients with AVM of IV-V grades according to Spetzler-Martin
Оптимизация тактики эндоваскулярного лечения больных с большими и гигантскими церебральными артериовенозными мальформациями / Р. Р. Байрамов, П. И. Никитин, В. С. Панунцев, К. Ю. Орлов // Якутский медицинский журнал. – 2011. – N 1 (33). – C. 50-54.