Иммунологическая характеристика хронических алкогольных и алкогольно-вирусных гепатитов
Статья в журнале
Русский
Библиогр.: с. 120 (12 назв.)
616.36-002.5-085
алкоголь; вирус; хронический алкогольный гепатит; хронический алкогольно-вирусный гепатит; иммуноглобулин; иммунологическая характеристика; иммунные реакции; иммуноглобулин; сыворотка крови; Т-лимфоциты; alcohol; viruss; chronic alcoholic hepatitis; chronic alcohol-virus hepatitis; immunoglobulin; immunological characteristics; immune responses; immunoglobulin; serum; T-lymphocite
Медицина и здравоохранение / Клиническая медицина / Гастроэнтерология и гепатология
Вестник Северо-Восточного федерального университета им. М. К. Аммосова. – 2017. – N 04 (09)
C. 117-120
Вестник Северо-Восточного федерального университета им. М. К. Аммосова
Якутск, Северо-Восточный федеральный университет
2222-5404 (print)
РИНЦ 2017: 0,237
In recent years, many facts have accumulated, indicating that immune reactions play a significant role in the pathogenesis of viral liver damage [1, 3]. The manifestation of a violation of the humoral component of immunity in patients with chronic viral hepatitis and cirrhosis is the change in the concentration of immunoglobulins in blood scrum Some authors note an increase in immunoglobulins of classes M and G. while others indicate a polyclonal increase in the concentration of all classes of immunoglobulins A, M, G [2, 4, 5], which is considered to be characteristic of chronic viral hepatitis, immunoglobulin G. In cirrhotic patients with viral etiology, as a rule, an increase in all three classes of immunoglobulins [1, 6] Лnumber of researchers have received evidence in favor of the role of the CEC in the emergence of organ and tissue damage in chronic viral liver lesions Many authors point to an increase in the CIC in the serum m chronic liver lesions of viral genesis with extrahepatic manifestations. I he study of the features of changes in the immune system of combined (virus + alcohol) liver damage, depending on the activity of the disease, the development of clinical and immunological characteristics and criteria for differential diagnosis in this pathology.as well as predicting the outcome of the disease is currently relevant and requires a more in- depth study of this problem The manifestation of a violation of the humoral component of immunity in patients with chronic viral hepatitis and cirrhosis is the change in the concentration of immunoglobulins in blood scrum Alcoholic hepatitis is one of the most difficult diagnosed alcoholic liver lesions The complexity of diagnosing alcoholic hepatitis is due to the fact that in 7-11 % this disease is initially asymptomatic. With continued use of alcohol, the process becomes irreversible and either becomes chronic, giving periodically more and more severe exacerbations, or already for several months leads to the development of cirrhosis and lethal outcome [6, 7]
Чибыева, Л. Г. Иммунологическая характеристика хронических алкогольных и алкогольно-вирусных гепатитов / Л. Г. Чибыева. М. И. Гатилова // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2017. — N 4 (09). — С. 117-120.
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