Венозный инсульт у пациентки молодого возраста: клиническое наблюдение
Статья в журнале
Русский
Библиогр.: с. 125 (6 назв.)
616-005-053.81
венозный инсульт; тромбоз синусов головного мозга; тромбоз церебральных вен; тромбофилия; магнитно-резонансная венография; нейровизуализация; сагиттальный синус; беременность; генетический скрининг; антифосфолипидный синдром; venous stroke; cerebral sinus thrombosis; cerebral vein thrombosis; thrombophilia; magnetic resonance venography; neuroimaging; sagittal sinus; pregnancy; genetic screening; antiphospholipid
Медицина и здравоохранение / Клиническая медицина / Кардиология и ангиология, Медицина и здравоохранение / Клиническая медицина / Акушерство и гинекология
Вестник Северо-Восточного федерального университета им. М. К. Аммосова. – 2017. – N 04 (09)
C. 121-125
Вестник Северо-Восточного федерального университета им. М. К. Аммосова
Якутск, Северо-Восточный федеральный университет
2222-5404 (print)
РИНЦ 2017: 0,237
Venous stroke is one of the rare forms of acute cerebral circulation disorders. The disease develops due to the thrombosis of the brain veins or sinuses. The venous stroke causes are conditions associated with thrombophilia including the antiphospholipid syndrome, pregnancy, sepsis, oral contraceptive use, malignant neoplasms and other diseases. In some cases, the venous stroke cause remains unclarified. The venous stroke etiological factor establishing requires a multifaceted examination, including genetic screening for congenital thrombophilia. This article presents the clinical case of the venous stroke in a young patient. The disease developed in the postpartum period. The clinical manifestations were characterized by the presence of cerebral, meningeal symptoms and convulsive syndrome. The laboratory examination revealed thrombocytosis, hypochromic anemia. The brain magnetic resonance imaging with venography diagnosed the sagittal sinus thrombosis and small area of cytotoxic edema. Examination of somatic status did not reveal the signs of systemic, infectious, oncological diseases. The genetic study was carried out to identify the polymorphism variants, including 677 C / T of MTHFR gene, 1298AC of MTHFR gene, 66 AG of MTRR gene, 2756 AG of MTR gene, 20210 GA of F2 gene, 1691 GA of F5 gene. This genetic screening did not reveal the risk factors for congenital thrombophilia. We carried out the anticoagulant, antiplatelet, anti-edematous, neuroprotective therapy, and the neurological symptoms were regressed, thrombocytosis index decreased, the diameter of the sagittal sinus thrombus decreased. In this clinical case, the cerebral sinus thrombosis developed due to the changes in the hormonal status and blood coagulation properties on the background of pregnancy and childbirth. In clinical practice, it is necessary to pay special attention to the possible risks of cerebral sinuses and veins thrombosis during pregnancy and postpartum period. In addition, it is necessary to examine the carriage of genetic congenital thrombophilia risk factors in young venous stroke patients
Венозный инсульт у пациентки молодого возраста: клиническое наблюдение / С. А. Чугунова, Т. Я. Николаева, А. В. Игнатьева [и другие] // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2017. — N 4 (09). — С. 121-125.
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