Микробиологическая диагностика туберкулеза в Республике Саха (Якутия)
Книга или сборник статей
Русский
616-002.5(571.56)
туберкулез; лекарственная чувствительность; множественная лекарственная устойчивость; широкая лекарственная устойчивость; tuberculosis; mycobacterium tuberculosis; drug sensitivity; multidrug resistance; extensive drug resistance
Медицина и здравоохранение / Клиническая медицина / Пульмонология
Analysis of trends in statistics for smear-positive patients (MTB+) over the period from 2011 to 2016 showed that number of registered MTB+ patients with active pulmonary tuberculosis had decreased during the study period, both among all cases, and among new cases. Nonetheless, the size of infection reservoir defined as the number of MTB+ patients remains at high levels. We observed high rates of prevalence for drug-resistance, including multidrug resistance and extensive drug resistance (MDR and XDR). Prevalence rates of tuberculosis cases with MDR in Yakutia in the years 2013 to 2015 were higher than the same rates over Russian Federation by factors of 1.7-1.8-1.6, but showed a trend to decrease compared to the rates in the Far East Federal District. High proportion of newly identified patients with MDR among patients with drug-resistant tuberculosis (up to 68.5%) suggests the emergence of a totally new-made tuberculosis infection reservoir with resistance to first-line drugs. The policy pursued and supported in the Sakha Republic (Yakutia) is aimed at strengthening laboratory capabilities, adopting novel diagnostic technologies, improving epidemiologic surveillance, while supporting the currently running state programs against tuberculosis, and considering the currently observed decrease in tuberculosis incidence, this could lead to beneficial effect on existing and future burden of drug-resistant tuberculosis
Микробиологическая диагностика туберкулеза в Республике Саха (Якутия) / Г. И. Алексеева, М. В. Черных, Н. Г. Павлов [и другие] // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 3-10.
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