Взаимосвязь болезни Паркинсона и эссенциального тремора: обзор литературы и клинический случай
Статья в журнале
Русский
Библиогр.: с. 49 (18 назв.)
616.858-008.6
нейродегенерация; тремор; болезнь Паркинсона; эссенциальный тремор; диагностика; патофизиология; подкорковые образования; мозжечок; экстрапирамидная система; дофамин; neurodegeneration; tremor; Parkinson’s disease; essential tremor; diagnosis; pathophysiology; subcortical structures; cerebellum; extrapyramidal system; dopamine
Медицина и здравоохранение / Клиническая медицина / Неврология, Медицина и здравоохранение / Клиническая медицина / Психиатрия и психотерапия
Вестник Северо-Восточного федерального университета им. М. К. Аммосова. – 2018. – N 2 (11)
C. 44-49
Вестник Северо-Восточного федерального университета им. М. К. Аммосова
Якутск, Северо-Восточный федеральный университет
2222-5404 (print)
РИНЦ 2017: 0,237
Parkinson’s disease and essential tremor are the most common neurodegenerative diseases, which are accompanied by the development of tremor - involuntary rhythmic hyperkinesis. In the essential tremor,tremor has a kinetically postural character with a frequency of 6 to 10 Hz, affectingarms, head, face, vocal cords, tongue, legs and trunk. Parkinson tremor has a frequency of 4-6 Hz, occurring at rest in the form of “counting coins” or “rolling pills”, decreasing with active movements until complete disappearance, and is characterized by resumption after 2 or more seconds after giving the pose (“renewed” tremor). The generation of tremors is associated with dysfunction of two main ways: basal nuclei - cerebellum - thalamus and cogwheel - olive complex. Consequently, damage to any of these levels leads to the development of tremors. Recently, the concept of a single continuum of essential tremor - Parkinson’s disease - is widely discussed.It has been established that these neurological disorders can coexist or transit into each other. So, essential tremor increases the risk of developing Parkinson’s disease by 3.5 times, and in patients with Parkinson’s disease the likelihood of attaching an essential tremor is as high. This is due to the cross pathophysiological mechanism, which is probably due to genetic mutations. This article discusses the pathophysiological mechanisms of the development of tremor in patients with Parkinson’s disease and essential tremor. We describe a patient with the essential tremor whose disease has been transformed into tremor predominant Parkinson’s disease
Таппахов, А. А. Взаимосвязь болезни Паркинсона и эссенциального тремора: обзор литературы и клинический случай /А. А. Таппахов, Т. Г. Говорова, Т. Е. Попова // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2018. — N 2 (11). — С. 44-49.
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