Количество страниц: 6 с.
The frequency of Del 19 and L858R mutations of the EGFR gene was studied among patients of the Yakut Republican Oncology Dispensary with lung adenocarcinoma (n=177). Mutations were found 3.8 times more commonly in female population than in male. Mutations were detected 2.8 times more regularly among patients with stages I and II of the disease in compare with stages III and IV. The mutation frequency was 3.4 times over in the Sakha (Yakut) ethnic group patients as opposed to Russian ethnic group. In addition the mutation frequency was 9.6 times over in the Sakha (Yakut) ethnic group male patients as opposed to Russian ethnic group. It was shown that the overall 36-month survival of patients with a positive status of EGFR mutations increases by 2.5 times (from 29.3% to 74.1%). Moreover in patients with stages I and II of the disease, survival rate increases by 1.4 times, in patients over 65 years old in 2.9 times, in female patients in 2.4 times.
Мутации гена EGFR (DEL19/L858R) при аденокарциноме легкого у пациентов якутского республиканского онкологического диспансера / Михайлов Ю. Н., Филиппов Э. В., Филиппова Г. В., Иванова Ф.Г. [и др.] ; ГБУ РС(Я) "Якутский республиканский онкологический диспансер", Институт биологических проблем криолитозоны, Северо-Восточный федеральный университет им. М. К. Аммосова // Якутский медицинский журнал. - 2024. - N 3 (87). - С. 83-88. - DOI: 10.35789/YMJ.3034.87.17
DOI: 10.35789/YMJ.3034.87.17
Количество страниц: 5 с.
The impact of COVID-19 incidence on long-term cardiovascular endpoints in patients with sick sinus syndrome (SSS) and with an implanted pacemaker has been studied. Patients with COVID-19 and no COVID-19 were examined. The follow-up period was 30 months and the endpoints were cardiovascular death, myocardial infarction, stroke and cardiovascular hospitalization. Comparison of the incidence of adverse cardiovascular endpoints in the COVID-19 and control groups showed no differences in all endpoints according to the chi-square test, with the exception of frequency of myocardial infarction in the “COVID-19”. The close relationship between tachybradicardia, microvascular dysfunction and coronary artery disease, and at the same time the impossibility of modulating the heart rhythm in the presence of vvegetative vascular dystonia and an established pacemaker assumed that autonomic dysfunction in postcoid patients caused myocardial ischemia and, as a result, an increase of myocardial infarction.
Влияние COVID-19 на отдаленные кардиоваскулярные конечные точки у пациентов с синдромом слабости синусового узла и имплантированным электрокардиостимулятором / Бадыков М. Р., Лакман И. А., Бадыкова Е. А., Плечев В. В. [и др ; Башкирский государственный медицинский университет, Уфимский университет науки и технологий, Северо-Восточный федеральный университет им. М. К. Аммосова // Якутский медицинский журнал. - 2024. - N 3 (87). - С. 79-83. - DOI: 10.25789/YMJ.2024.87.16
DOI: 10.25789/YMJ.2024.87.16
Количество страниц: 6 с.
Ап algorithm for assessing the professional potential of an otorhinolaryngologist based on the identification of medical risk factors in the provision of medical care to patients with rhinosinusitis has been developed, otorhinolaryngologists from 32 subjects of the Russian Federation were screened and the treatment of patients with polyposis rhinosinusitis was analyzed. The proposed methodological approach was successfully used to assess the knowledge and skills of physicians of other specialties and formed the basis for the methodology of studying the professional potential of physicians, for which the author's invention certificates were also obtained
Методология определения медицинской детерминанты общественного здоровья с выявлением медицинских факторов риска нарушения здоровья в оториноларингологии (на примере анализа лечения полипозного риносинусита) = Methodology for determining the medical determinant of public health with the identification of medical risk factors for health disorders in otorhinolaryngology (on the example of analyzing the treatment of polyposis rhinosinusitis) / С. В. Русских, Е. Л. Савлевич, Т. П. Васильева, Е. А. Тарасенко, Л. Н. Афанасьева, А. В. Шурупина, Ю. В. Арсенина ; НИИ общественного здоровья им. Н. А. Семашко, МОНИКИ им. М. Ф. Владимирского, Северо-Восточный федеральный университет им. М. К. Аммосова // Якутский медицинский журнал. - 2024. - N 3, (87). - С. 57-62. Рез. также англ. - Библиогр.: с. 61-62 (14 назв.). - Разработан алгоритм оценки профессионального потенциала врача-оториноларинголога на основе выявления медицинских факторов риска при оказании медицинской помощи пациентам с риносинуситом. Проанкетированы врачи-оториноларингологи из 32субъектов РФ и проведен анализ лечения пациентов с полипозным риносинуситом. Методический подход был успешно апробирован для оценки знаний и умений врачей других специальностей и положен в основу методологии изучения их уровня профессионального потенциала. - Ап algorithm for assessing the professional potential of an otorhinolaryngologist based on the identification of medical risk factors in the provision of medical care to patients with rhinosinusitis has been developed, otorhinolaryngologists from 32 subjects of the Russian Federation were screened and the treatment of patients with polyposis rhinosinusitis was analyzed. The proposed methodological approach was successfully used to assess the knowledge and skills of physicians of other specialties and formed the basis for the methodology of studying the professional potential of physicians, for which the author's invention certificates were also obtained.
DOI: 10.25789/YMJ.2024.87.11
Год выпуска: 2021
Год выпуска: 2024
Год выпуска: 2024
Источник: Жизнь Якутска. - 2018. - 8-15 ноября. - С. 18.
Количество страниц: 1 с.
Количество страниц: 8 с.
Diamond-Blackfan anemia (DBA) is a rare form of congenital red cell aplasia of hematopoiesis in infants and children, characterized by suppression of erythropoiesis and congenital malformations. The article presents an observation of a child with DBA. The girl was born with severe anemia. The diagnosis was established at the age of 3 months, genetically confirmed at 2 years. Since her birth, she had been receiving monthly transfusion therapy with red blood cells. Treatment with prednisolone, L-leucine was carried out without effect, the child remained transfusion-dependent. The only curative method for this disease is hematopoietic stem cell transplantation (HSCT). With a 14-year-old sibling not suitable, there was no other suitable related donor. By the age of 15, the child had developed serious complications caused by post-transfusion iron overload of the liver (grade 4), myocardium, pituitary gland with the development of liver and heart failure; endocrine disorders in the form of hypopituitarism, primary and secondary hypothyroidism, increased fasting glycemia. In addition, the girl has chronic viral hepatitis C. In order to remove excess iron from the body, the patient has been receiving chelation therapy since the age of 8. The accumulation of iron in organs leads to irreversible dysfunction, reducing the life expectancy of patients with DBA, so early initiation of chelation therapy is necessary.
Анемия Даймонда-Блекфена с тяжелой пострансфузионной перегрузкой железом / Аргунова Е. Ф., Харабаева Е. М., Протопопова Н. Н., Кондратьева С. А. [и др.] ; Северо-Восточный федеральный университет им. М.К. Аммосова, Медицинский институт, ГАУ РС (Я) "Республиканская больница N 1 - Национальныйцентр медицины имени М. Е. Николаева" // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки. - 2024. - N 4 (37). - C. 10-17. - DOI: 10.25587/2587-5590-2024-4-10-17
DOI: 10.25587/2587-5590-2024-4-10-17
Количество страниц: 5 с.
Being the core of the scientific community, scientific schools play a special role in the formation of civil society. In addition to purely subject content, a scientific school is essentially an effective model of education as a transmitter of cultural norms and values of the scientific community from the older to the younger generation. The scientific school “Physiological and Medical Aspects of Health of Various Population Groups in the Sakha Republic (Yakutia)” is an example of organizing interdisciplinary research devoted to the problem of human health in the extreme conditions of the North and its interaction with the ecology of the environment. The article is dedicated to the founder of the scientific school, Academician of the Academy of Sciences of the Sakha Republic (Yakutia), Doctor of Medical Sciences, Professor Palmira Georgievna Petrova.
Борисова, Н. В. Научная школа академика Петровой П. Г. / Борисова Н. В. ; Северо-Восточный федеральный университет им. М. К. Аммосова, Медицинский институт // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки. - N 4 (37). - C. 5-9. - DOI: 10.25587/2587-5590-2024-4-5-9
DOI: 10.25587/2587-5590-2024-4-5-9