Место работы автора, адрес/электронная почта: Республиканская больница N 1 - Национальный центр медицины, Педиатрический центр ; 677010, г. Якутск, ш. Сергеляхское, 4 ; http://rb1ncm.ru/
Область научных интересов: Педиатрия, детская онкология, гематология
Количество страниц: 3 с.
The article presents а clinical case of a rare inflammatory myofibroblastic tumor of the abdominal cavity in a 6-year-old boy. The child had a high fever, laboratory tests revealed an increase in acute phase proteins, and according to instrumental studies - a large tumor of the abdominal cavity, without a clear organ affiliation. During laparoscopic revision, the possibility of total tumor removal was established; laparotomy was performed and the tumor was radically removed
Редкий случай воспалительной миофибробластической опухоли брюшной полости у ребенка / C. A. Николаева, В. Б. Егорова, C. A. Кондратьева, А. Ю. Тарасов, Е. П. Яковлев, Я. А. Мунхалова, С. А. Евсеева // Якутский медицинский журнал. - 2024. - N 1 (85). - С. 132-135. - DOI: 10.25789/ҮШ.2024.85.34
DOI: 10.25789/ҮШ.2024.85.34
Количество страниц: 6 с.
Pearson syndrome (PS) is a rare multisystem disease with predominant involvement of the hematopoietic organs, pancreas and liver, developing due to a defect in mitochondrial DNA. Most often, the first clinical manifestations of Pearson syndrome in the form of anemia of varying severity appear in the first year of life. The disease was first described in 1979 by Howard Pearson, who included in this syndrome sideroblastic anemia, vacuolation of hematopoietic progenitor cells in the bone marrow, exocrine pancreatic dysfunction, and early onset of the disease, usually before the age of 1 year. According to the literature, the incidence of Pearson syndrome is 1:5000. This article presents a clinical case of a boy diagnosed with Pearson syndrome at the age of 6 months. The child had pale skin from birth and a general blood test showed severe anemia. In the myelogram: Moderate increase in proliferation of the erythroid germ with impaired maturation, diserythro and dysmegakaryocytopoiesis, moderate monocytosis, ring-shaped sideroblasts 45 %. In a molecular genetic study: on DNA material isolated from the patient’s blood cells and urinary sediment using the polymerase chain reaction of very long fragments, the patient was analyzed for the presence of mitochondrial DNA deletions in the region where most of the major changes were described (m.6380-m. 16567). DNA isolated from the patient’s blood cells and urine sediment revealed a deletion of about 3000 bp. in a homoplasmic state. The boy also has neurological disorders. Currently, the child is admitted monthly to the oncology department of the pediatric center for replacement therapy with blood components. He has been observed by hematologists together with neurologists. He also receives chelation therapy and methylprednisolone therapy on an ongoing basis. For anticonvulsant purposes: vigabatrin. Symptomatic therapy, according to the recommendations of the federal center: Courses of Riboflavin, Tocopherol (vitamin E), Coenzyme Q, Succinic acid, L-carnitine, Thiamine.
Клинический случай синдрома Пирсона у ребенка в Республике Саха (Якутия) / О. В. Ядреева, Е. М. Харабаева, В. Б. Егорова [и др.] ; ГАУ РС (Я) "Республиканская больница N 1 им. М. Е. Николаева", Северо-Восточный федеральный университет им. М. К. Аммосова, Медицинский институт // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки. - 2024. - N 2 (35). - C. 70-75. - DOI: 10.25587/2587-5590-2024-2-70-75
DOI: 10.25587/2587-5590-2024-2-70-75
Количество страниц: 3 с.
Клинический случай мегалобластной анемии у подростка в сочетании с COVID-19 / Е. Ф. Аргунова, С. А. Николаева, С.А. Кондратьева [и др.] ; Республиканская больницы N 1 - Национального центра медицины, Северо-Восточный федеральный университет им. М. К. Аммосова, Медицинский институт // Якутский медицинский журнал. - 2023. - N 3 (83). - C.123-125. - DOI: 10.25789/YMJ.2023.83.31
DOI: 10.25789/YMJ.2023.83.31
Количество страниц: 6 с.
In the period 2003-2016, 6 patients with a diagnosis of megaloblastic anemia passed through the Oncology Department of the Pediatric Center (PDT) of the Republic’s Hospital 1- National Center of Medicine. The average age of children was 13 years. In the clinical picture, pronounced anemic syndrome prevailed. On the part of the gastrointestinal tract, inflammatory changes predominated, in the form of esophagitis, gastritis, duodenitis. One boy hadatrophic gastritis. Changes in the nervous system, in the form of numbness of the fingers and toes, were present only in one girl. The patients’ hemograms showed hyperchromic anemia of severe degree, leukopenia, and thrombocytopenia. In 3 children, the level of folate was determined; in 4 children - the activity of vitamin B12 in serum; in 2 - the level of folate was lower than normal; with the activity of vitamin B12 low in all the examined. Two children were assessed for the level of folate red blood cells, which also turned out to be below normal. According to the survey, a combination deficit of vitamin B12 and folic acid was found in two patients. The cause of megaloblastic anemia was insufficient nutrition (rejection of animal products), diphyllobothriasis, and atrophic gastritis. In three children, the cause of anemia remained unclear. With timely diagnosis and adequate therapy, taking into account the underlying cause, this disease can be treated with a favorable prognosis
Мегалобластные анемии у детей / Е. Ф. Аргунова, С. А. Кондратьева, О. В. Ядреева, Н. Н. Протопопова // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2018. — N 3 (12). — С. 12-16.
Количество страниц: 6 с.
Хронический миелоидный лейкоз у детей Республики Саха (Якутия) / Е. Ф. Аргунова, С. А. Кондратьева, С. А. Николаева [и другие] // Вестник Северо-Восточного федерального университета им. М. К. Аммосова. Серия: Медицинские науки.— 2019. — N 3 (16). — С. 18-22.— DOI: 10.25587/SVFU.2019.3 (16).39452
DOI: 10.25587/SVFU.2019.3(16).39462
Количество страниц: 4 с.
Клинический случай синдрома Вискотта-Олдрича / О. Н. Иванова, Т. Е. Бурцева, Н. Н. Протопопова, С. А. Кондратьева, Д. М. Фурман, М. П. Слободчикова // Якутский медицинский журнал. — 2020. — N 2 (70). — С. 104-106. – DOI: 10.25789/YMJ.2020.70.31.
DOI: 10.25789/YMJ.2020.70.31
Количество страниц: 4 с.
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Педиатрия,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Онкология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина.
The article analyzes the incidence of cancer in children and adolescents of the Republic of Sakha (Yakutia) from 2000 to 2015 according to the data of appeal and hospitalization in medical institutions.
Динамика показателя заболеваемости детей и подростков онкологическими заболеваниями в Республике Саха (Якутия) / Т. Е. Бурцева, Л. Н. Афанасьева, Е. Ф. Аргунова, Л. А. Николаева, С. А. Кондратьева, Е. М. Харабаева, С. А. Николаева, С. А. Евсеева, В. Г. Часнык, П. М. Иванов, Ф. Ф. Федоров, К. И. Бурнашева// Якутский медицинский журнал. — 2018. — N 3 (63). — С. 66-69. — DOI: 10.25789/YMJ.2018.63.22.
DOI: 10.25789/YMJ.2018.63.22
Количество страниц: 4 с.
The article presents the analysis of frequency indicators: primary morbidity, mortality in acute leukemia in children of the RS (Y) for the period from 2000 to 2016. The incidence of acute leukemia, acute lymphoblastic leukemia, acute non-lymphoblastic leukemia in children’s population of the RS (I) are average and comparable with that of other regions of the Russian Federation. In dynamics there is a decrease in mortality from leukemia and this is due to the improvement of therapy and the quality of accompanying therapy.
Эпидемиология острых лейкозов у детей Республики Саха (Якутия) / Е. Ф. Аргунова, С. А. Кондратьева, Е. М. Харабаева, О. В. Ядреева, С. А. Николаева, Н. Н. Протопопова, С. Н. Алексеева, С. А. Евсеева, Т. Е. Бурцева, В. С. Баланова// Якутский медицинский журнал. — 2018. — N 3 (63). — С. 63-66. — DOI: 10.25789/YMJ.2018.63.21.
DOI: 10.25789/YMJ.2018.63.21
Количество страниц: 4 с.
The article presents the clinical case of management of a child with a genetic metabolic disease until setting a correct diagnosis propionic acidemia. The full – term child aged 11 days had developed metabolic crisis, which was taken as an expression of neonatal pathology, such as neonatal jaundice, perinatal CNS lesion. On a background of detoxification the patient had the clinical positive dynamics, but a bright period lasted only two weeks. Due to a main disease the child had secondary immunodeficiency, which resulted in recurrent pneumonias. The patient was examined in three ways: changes of peripheral blood – leukopenia, thrombocytopenia, anemia; neurological symptoms – soporous condition, lethargy, refusal of meals, oppression of all reflexes, muscular hypotension; in view of anamnesis, impossibility of a comparison all the clinical symptoms to one diagnosis tap genetic research. The lack of the methodology of tandem mass spectrometry extended the time of correct diagnosis and timely treatment.
Клинический случай пропионовой ацидемии / С. Н. Алексеева, А. Л. Сухомясова, Г. И. Софронова, З. П. Андросова, С. А. Кондратьева, Е. Е. Гуринова, П. В. Павлова // Якутский медицинский журнал. — 2018. — N 3 (63). — С. 99-102 – DO: 10.25789/YMJ.2018.63.32 .
DOI: 10.25789/YMJ.2018.63.32