Количество страниц: 6 с.
To assess the effectiveness microscopic methods used in the Phthisiatry Research-Practice Center, we comparatively studied the results of Ziehl-Neelsen microscopy, fluorescence microscopy and LED-microscopy in detecting acid-fast bacilli (AFB).We comparatively analyzed (using Ziehl-Neelsen microscopy) a total of 400 positive smears with AFB detected by fluorescence microscopy, and specimens from 648 patients treated at Pulmonology department of the Yakutsk City Clinical Hospital, who were tested by their clinical diagnostic laboratory as negative for AFB after triple Ziehl-Neelsen microscopy of intact sputum. For comparative analysis between fluorescence and LED microscopy, specimens from 1082 new pulmonary tuberculosis patients were studied
Сравнительные исследования результативности бактериоскопических методов по Цилю-Нильсену, люминесцентной и led микроскопии в выявлении кислоустойчивых микобактерий / Н. Г. Павлов, Г. И. Алексеева, М. В. Черных [и другие] // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 87-92.
Количество страниц: 6 с.
Presented is the description of laboratory service responsible for microbiological diagnosis of tuberculosis in Sakha Republic (Yakutia). We analyzed results of tuberculosis detection performed using microscopy with Ziehl-Neelsen staining in clinical diagnostic laboratories of the primary healthcare facilities, in 2005 and over the period from 2012 to 2016. For the purposes of comprehensive assessment of the effectiveness of microscopic detection of acid-fast mycobacteria, the process of deriving indicative criteria values was scrutinized. Employing the criteria analyzed, we assessed effectiveness and quality of laboratory work on microscopic detection of acid-fast mycobacteria, and level of organization of workflow during detection of tuberculosis patients in primary healthcare facilities, based on Ziehl-Neelsen microscopy
Комплексный индикативный анализ эффективности выявления кислотоустойчивых микобактерий в республике Саха (Якутия) / Н. Г. Павлов, Г. И. Алексеева, М. К. Винокурова [и другие] // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 82-87.
Количество страниц: 6 с.
Despite the decrease in incidence of pediatric tuberculosis following measures implemented by the Ministry of Health of the Sakha Republic (Yakutia), with support from the Government of the Sakha Republic (Yakutia), the problem of pediatric tuberculosis remains urgent in the arctic and northern districts. Over 5 years, tuberculosis (TB) was detected in 161 children aged 0 to 14, among the 34 administrative districts of Yakutia republic, of them, children from arctic and northern areas made 24.8% (40). Lack (67%) of TB doctors in the arctic and northern districts undermines the performance of activities on early detection and prevention of TB among the population. Analysis of business trips showed that anti-tuberculosis measures conducted were insufficient, due isolated, hard-to-access location of settlements, long distance from the administrative center, lack of permanent employee in some of the districts. Out of the 12 districts, 9 districts (75%) managed to conduct meetings at the level of municipal entity to discuss issues in TB control work. 24 medical councils to discuss ways to conduct TB control activities and successfulness of conducted activities were summoned in central district hospitals of 11 districts (91.6%). 42 orders on conducting TB control measures and TB prevention among the population were issued in 11 central district hospitals. Decline in pediatric tuberculosis incidence in arctic and northern districts can be achieved only by better conducting anti-TB activities, which should lead ultimately to lower pediatric TB incidence over the republic
Ощепкова, Н. М. Особенности организации противотуберкулезной работы среди детского населения в условиях северных и арктических территорий / Н. М. Ощепкова, М. К. Винокурова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 78-82.
Количество страниц: 10 с.
42 tuberculosis infection hotspots with the presence of multidrug-resistance (MDR) were studied in Yakutsk, a city with 82 children with tuberculosis aged 0 to 17, who are registered for regular medical check-up at the Pediatric TB Clinic of the Phthisiatry Research-Practice Center. АКТУАЛЬНЫЕ ПРОБЛЕМЫ СОЧЕТАННЫХ ИНФЕКЦИЙ Most of currently existing tuberculosis hotspots, i.e. domiciles with the presence of MDR in Yakutsk have unsatisfactory living conditions (69%), material support below poverty level (21.4%), and, as a rule, unsanitary conditions (64.3%). The study showed that children living in MDR-hotspots were exposed to higher infection risk; 10% of children examined during contact tracing had active tuberculosis disease, which was directly attributable to delayed detection of tuberculosis in adults. Arrangement of early tuberculosis detection in adult population, improvements in housing and material well-being, more effective anti-epidemic activities at MDR-hotspots are needed to help reduce the incidence of tuberculosis in children
Ощепкова, Н. М. Особенности очагов туберкулезной инфекции с множественной лекарственной устойчивостью в условиях северного города / Н. М. Ощепкова, М. К. Винокурова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 69-78.
Количество страниц: 6 с.
Polychemotherapy is required to treat all forms of tuberculosis, especially drug-resistant disease, but leads to considerable medication load on patient, causing various disturbances in vital functions. We analyzed the most common reasons for patient transfer to Anesthesia, Resuscitation, and Intensive Care Unit. In 2016, a total of 473 patients were admitted to Intensive Care Unit, of them 306 (647%) males and 167 (35.3%) females aged 1 to 91 years. They spent a total of 1528 bed-days; mortality rate 3% (14 patients). 15 patients underwent a total of 168 extracorporeal detoxication sessions. A total of 474 anesthesia supports were performed, of them 443 (93.5%) routine, and 31 (6.5%) emergency. Due to severity of their condition, 33 patients from the Department for Multidrug-Resistant Tuber- 59 Preventing spread of tuberculosis infection in circumpolar regions of Russia. Current problems in co-infection culosis needed to be admitted to Intensive Care Unit for critical therapy, which made 7% out of a total number of patients. They spent 199 bed-days in intensive care (13% of a total member of bed-days). Patients who died made 21.4% of all patients who died, including 9.1% of patients with multidrugresistant tuberculosis (MDR TB). Advanced tuberculosis disease was the cause of deaths. 5 patients transferred from MDR TB Department underwent plasmapheresis due to toxic hepatitis, a total of 31 sessions. Anesthesia supports were provided to 110 patients transferred from MDR TB Department, which made 23.2% of all analgesias. Patients with MDR TB who were surgically treated and received anesthesia support, mostly had infiltrating TB (61.9%), fibrocavitary TB (16.7%), or disseminated TB (9.5%)
Макарова, Т. С. Коньюнктурный обзор больных, поступивших в отделение анестезиологии и реанимации с туберкулезом множественной лекарственной устойчивостью возбудителя / Т. С. Макарова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 58-63.
Количество страниц: 4 с.
Examination of surgical specimens provides the richest insight into M.tuberculosis, its species, and drug susceptibility. Rapid identification of drug susceptibility directly from surgical specimens is crucial for timely adjustment of chemotherapy. This is possible with molecular genetic tests, which produce results after 2-3 days. The following findings were obtained after analysis of 78 specimens: 1) agreement between M.tuberculosis drug susceptibility results determined with surgical specimens and sputum specimens was 42.4% (14) out of 33 sputum specimens; 2) discordance in determining drug susceptibility was 57.6% (19); 14 patients had negative sputum test results, but molecular genetic test results were positive
Эффективность ПЦР в реальном времени в определении лекарственной устойчивости микробактерий туберкулеза в операционном материале / Л. И. Мордовская, И. И. Винокуров, А. А. Корнилов, С. Д. Алексеева, Н. Н. Горохова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 67-69.
Количество страниц: 6 с.
Beijing and non-Beijing genotypes of M.tuberculosis were determined in 473 patients confirmed as infectious cases and hospitalized for treatment to the Phthisiatry Research-Practice Center. Strains belonging to Beijing family were predominant (62.6%). Patients with Beijing genotype strains of M.tuberculosis (MTB) had high levels of multidrug-resistance compared to patients with non-Beijing MTB. Residents of western Yakutia had larger proportion of patients with multidrug-resistance, compared to Arctic area. Up to 80% of patients residing in eastern Yakutia had preserved drug susceptibility
Мордовская, Л. И. Распространенность генотипов beljing unonbeiljing микробактерий туберкулеза у больных туберкулезом в Республике Саха (Якутия) / Л. И. Мордовская, С. Д. Алексеева, М. В. Егорова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 63-67.
Количество страниц: 4 с.
According to reports for the year 2017, principal epidemiological indicators for tuberculosis in Yakutsk exceeded the average rates over republic: total incidence was 1.4 higher; prevalence and number of infectious cases were 1.6 higher; mortality was 1.2 higher. Epidemiological situation in Yakutsk is aggravated by influx of former prisoners released from Federal Penitentiary Service facilities located near Yakutsk, boosting one of the most dangerous and poorly controlled pools of tuberculosis infection. Despite difficulties in conducting treatment, Yakutsk City Antituberculosis Dispensary has been working fairly effectively
Лукина, А. М. Об эпидемиологической ситуации по туберкулезу в г. Якутске / А. М. Лукина // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 56-58.
Количество страниц: 8 с.
Случай вспышки туберкулеза с множественной лекарственной устойчивостью среди студентов Верхневилюйского техникума / Е. Ф. Лугинова, Н. Ю. Петухова, Е. М. Немытышева [и другие] // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 50-56.
Количество страниц: 6 с.
Rate of primary M.tuberculosis infection is considered one of the important indicators describing epidemiological situation for tuberculosis in a region. Long-term trends of this indicator were analyzed. One of the findings was that between 2007 and 2016 primary infection rate was declining fast, suggesting improvement in the epidemiological situation in the Sakha Republic overall
Лугинова, Е. Ф. Анализ динамики показателя первичной инфицированности среди детского населения Республики Саха (Якутия) / Е. Ф. Лугинова // Предупреждение распространения туберкулезной инфекции в циркумполярных регионах России. Актуальные проблемы сочетанных инфекций (ВИЧ/ТБ/гепатиты) — 2018. — С. 46-50.