Место работы автора, адрес/электронная почта: Якутский научный центр комплексных медицинских проблем ; 677010, г. Якутск, ш. Сергеляхское, 4 ; http://mednauka.com
Количество страниц: 5 с.
In this work an assessment of the allostatic reaction of the thyroid gland was carried out in residents of Yakutia using the mathematical model SPINA, in the winter-spring period, at negative atmospheric temperatures (from -47°C to -11°C). A change in the homeostasis of the hypothalamus-pituitary-thyroid axis (type 2 allostasis) at low ambient temperatures was detected in 70% of the examined persons living in extremely cold climatic conditions of central Yakutia.
Аллостаз щитовидной железы 2 типа у жителей Якутии / А. А. Никанорова, Т. В. Борисова, В. Г. Пшенникова [и др.] ; Якутский научный центр комплексных медицинских проблем, Северо-Восточного федерального университета им. М. К. Аммосова, Институт естественных наук // Якутский медицинский журнал. - 2024. - N 2 (86). - С. 80-84. - DOI: 10.25789/YMJ.2024.86.19
DOI: 10.25789/YMJ.2024.86.19
Количество страниц: 4 с.
Seasonal variations in the levels of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) in young men in Yakutia were studied, where strong changes in climatic parameters in the winter-spring period (from -41.8°C to -0.2°C) were noted. Seasonal variations between winter and spring were found for fT3, where in winter its levels were lower - 6.48±0.31 pmol/L than in spring - 6.88±0.1 pmol/L (p=0.005). There were no statistically significant seasonal variations for TSH (U=97; p=0.914) and sv.T4 (U=47; p=0.112). Winter-spring seasonal variations of fT3 detected in this study there are signs of polar T3 syndrome in young men in Yakutia. To search for the causes of the detected seasonal variation, a correlation analysis of the levels of TSH, fT3 and fT4 was carried out depending on daylength and atmospheric air temperature. As a result, a correlation between fT3 and fT4 with the daylight (fT3: R=0.339, p=0.03; fT4: R=-0.346, p=0.01) and with air temperature (fT3: R=0.295, p=0.05; fT4: R=-0.296, p=0.04). No correlations were found with TSH levels (daylight: R=-0.06, p=0.69; air temperature: R=-0.09, p=0.559). Thus, the residents of Yakutia have signs of polar T3 syndrome, which can be associated with both a short light day and low atmospheric temperatures in winter. The results obtained may indicate an increase in the absorption of T3 at the tissue level when exposed to cold.
Признаки полярного Т3 синдрома у молодых мужчин в Якутии / А. А. Никанорова, Н. А. Барашков, В. Г. Пшенникова [и др.] ; Якутский научный центр комплексных медицинских проблем, Северо-Восточный федеральный университет им. М. К. Аммосова, Институт естественных наук // Якутский медицинский журнал. - 2024. - N 1 (85). - C. 5-8. - DOI: 10.25789/YMJ.2024.85.01
DOI: 10.25789/YMJ.2024.85.01
Количество страниц: 4 с.
The aim of this study is to evaluate the leptin level circulating in blood serum depending on the body mass index (BMI) in young healthy Yakuts (mean age 19.8±1.5 years). The total sample (n=281) was divided into three groups according to the WHO classification: persons with underweight, normal, overweight / obese. There were no statistically significant differences in BMI between men and women in the groups. As a result of the comparative analysis, it was found that both in women and in men, leptin levels were statistically higher in overweight/obese individuals compared with the other two groups. There were no statistically significant differences in leptin levels between the groups of people with underweight and normal weight, both in women and in men, which could be associated with the body's protection from low temperatures through the development of active brown adipose tissue, secreting additional leptin
Уровень циркулирующего в крови лептина у молодых якутов в зависимости от индекса массы тела / А. А. Никанорова, Н. Н. Готовцев, Н. А. Барашков [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 16-19
DOI: 10.25789/YMJ.2020.72.04
Количество страниц: 4 с.
Autosomal recessive deafness type 1A is one of the most frequent hereditary diseases in the Republic Sakha (Yakutia). The revealed features of the spectrum and frequency of pathogenic variants in the GJB2 gene in patients with congenital hearing impairment allow introducing routine DNA diagnostics into medical practice. The article discusses some of the bioethical issues of DNA testing of autosomal recessive deafness 1A type.
Некоторые биоэтические вопросы молекулярно-генетической диагностики аутосомно-рецессивной глухоты 1А типа, распространенной в якутской популяции / С. К. Кононова, Н. А. Барашков, В. Г. Пшенникова, А. В. Соловьев, А. М. Чердонова, А. А. Никанорова, Г. П. Романов, Э. К. Хуснутдинова, С. А. Федорова, Ф. М. Терютин // Якутский медицинский журнал. — 2018. — N 2 (62). — С. 79-82 — DO: 10.25789/YMJ.2018.62.23.
DOI: 10.25789/YMJ.2018.62.23
Количество страниц: 6 с.
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Оториноларингология,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина.
In this paper we present for the first time the results of the audiological and clinical-genealogical research of the population of settlements Batagai-Alyta and Kustur of the Eveno-Bytantaisky National District (ulus) of the Sakha Republic (Yakutia) for studying the postlingual form of deafness of unknown etiology firstly identified by us earlier in 3 Evens. As a result of an audiological examination of 72 people, 10 patients from 6 nuclear families who met the criteria of postlingual form of hearing loss were found. The segregation analysis carried out in these families confirmed the autosomal recessive type of inheritance of this form of postlingual hearing loss. The distant relationship of the examined patients with postlingual hearing loss living in two villages of the Eveno-Bytantaisky National District of the Sakha Republic can indicate to the role of the founder effect in the local prevalence of this pathology.
Постлингвальная глухота в Эвено-Бытантайском районе Якутии : аудиологический и клинико-генеалогический анализ / В. Г. Пшенникова, Ф. М. Терютин, Н. А. Барашков, Н. Н. Готовцев, А. А. Никанорова, А. В. Соловьев, Г. П. Романов, О. Л. Посух, Л. У. Джемилева, Э. К. Хуснутдинова, С. А. Федорова // Якутский медицинский журнал. — 2018. — N 4 (64). — С. 47-52. — DOI: 10.25789/YMJ.2018.64.14.
DOI: 10.25789/YMJ.2018.64.14
Количество страниц: 5 с.
- Чукчи – хранители вековых традиций > Современное положение,
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина.
We revealed the increased frequency of allele A rs2075577 of the UCP3 gene in populations of the Yakuts and Chukchi, living in low temperature conditions, that can be associated with random population effects or indicates the presence of adaptation mechanisms associated with thermoregulation.
Анализ полиморфизма SNP-маркеров генов несократительного термогенеза UCP1 (rs1800592), UCP2 (rs659366) и UCP3 (rs2075577) у якутов и чукчей / fА. А. Никанорова, Н. А. Барашков, Е. Е. Дьяконов, С. С. Находкин, В. Г. Пшенникова, А. В. Соловьев, С. С. Кузьмина, М. И. Томский, Т. Е. Бурцева, С. А. Федорова //Якутский медицинский журнал. – 2018. – N 2 (62). – C. 41-45.