Количество страниц: 4 с.
A comparative study of the blood immune cells functional activity in multiple sclerosis (MS) patients associated with the human endogenous retrovirus HERV - E λ 4-1 activation, as well as the immunomodulating properties of the homologous to a conservative region of hydrophobic transmembrane protein p15E 17 - amino acid synthetic oligopeptide was held. We found that multiple sclerosis patients with activated retrovirus HERV - E λ 4-1 are characterized by a higher blood immune cells functional activity, compared with healthy donors, as well as in MS patients, in whose blood mononuclear cells the expression of this retrovirus was not detected. Synthetic 17 - amino acid oligopeptide, homologous to the conservative region of the hydrophobic transmembrane protein p15E of the HERV retrovirus - E λ 4-1, increases the functional activity of blood mononuclear cells of MS patients, as well as the immune system central and peripheral organs cells and blood mononuclear cells of experimental animals in vivo. This oligopeptide’s effect was not genetically restricted.
Влияние эндогенного ретровируса HERV-Eλ 4-1 на функциональную активность клеток иммунной системы у больных рассеянным склерозом / И. А. Гольдина, Е. В. Маркова // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 32-35.
DOI: 10.25789/YMJ.2019.68.07
Количество страниц: 4 с.
We determined the contribution of the endocrine system to the formation of neurotic, stress-related disorders in order to identify the criteria for predicting their protracted course. A comprehensive clinical-psychopathological and hormonal examination of women with various types of the course of neurotic, stress-related disorders was performed. A psychopathological study of patients showed that overexertion of protective mental mechanisms associated with the impact of a stressful situation can lead to a breakdown in adaptation, disturbances of normal functioning and the emergence of various neurotic symptoms. We determined the hormonal criteria for predicting a protracted course of neurotic, stress-related disorders with the formation of a persistent personality changes at an early stage of the disease - at the stage of disorder of adaptive reactions.
Возможности прогнозирования течения невротических, связанных со стрессом расстройств, на основе гормональных показателей / В. Б. Никитина, О. Э. Перчаткина, М. М. Аксенов,А. К. Костин // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 51-54. – DOI: 10.25789/YMJ.2019.68.13.
DOI: 10.25789/YMJ.2019.68.13
Количество страниц: 5 с.
Врожденные пороки центральной нервной системы и эффективность их профилактики за 2000-2009 гг. в Республике Саха (Якутия) / А. Н. Ноговицына, Н. Р. Максимова, А. Л. Сухомясова, А. Н. Григорьева // Якутский медицинский журнал. – 2010. – N 4 (32). – С. 9-13.
Ответственность: Костенко Ольга Ивановна (Составитель), Николаева Татьяна Яковлевна (Прочие), Попова Татьяна Егоровна (Прочие)
Издательство: ИП Боголепов А. А.
Год выпуска: 2008
Количество страниц: 28 с.
Вторичная профилактика инсульта : методическое письмо / Министерство здравоохранения Республики Саха (Якутия) [и др.] ; составитель О. И. Костенко. - Якутск: ИП Боголепов А. А., 2008. - 24 с.
Количество страниц: 6 с.
Гетерогенность немоторных симптомов у пациентов с болезнью Паркинсона в Томской области / М. А. Никитина, Н. Г. Жукова, Е. Ю. Брагина, В. М. Алифирова, И. А. Жукова, Д. Е. Гомбоева, Н. Г. Бразовская, О. П. Ижболдина, И. Ж. Жалсанова // Якутский медицинский журнал. — 2019. — N 3 (67). — С. 70-74.
DOI: 10.25789/YMJ.2019.67.20
Количество страниц: 3 с.
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Неврология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Неврология,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология.
The purpose of the research work was the analysis of the ∆ 32 association of the gene CCR5 polymorphism with the risk of the multiple sclerosis development in the Russian and the Yakut population living on the territory of the Yakutia. Materials and methods: 63 patients with the reliable diagnosis of multiple sclerosis were examined according to the McDonald's criteria and 253 unallied healthy people selected on the basis of similarity to patients by age, sex and nationality characteristics were also surveyed. The polymorphic version ∆ 32 of CCR5 gene genotyping was carried out by polymerized chain reaction. Results: The Yakut population has no carriers of gene CCR5 deletion. The Russian population living on the territory of the republic has the frequency of CCR5 ∆ 32 allelic gene of 9,1%. There is a progressing speed increase in CCR5 ∆ 32- positive patients in comparison with CCR5 ∆ 32- negative ones (0.61±.013 versus 0.48±0.04).
Делеционный полиморфизм гена рецептора хемокина 5 и риск развития рассеянного склероза в Якутии / И. А. Николаева, Н. Р. Максимова, Т. Я. Николаева, В. П. Пузырев // Якутский медицинский журнал. – 2007. – N 2 (18). – C. 10-12.
Количество страниц: 4 с.
A clinical genealogical and molecular genetic analysis for the presence of mutations in the DRPLA gene in patients with an unidentified form of cerebellar syndrome in Yakutia was carried out. Expansion of CAG repeats in the DRPLA gene was found in four members of the Yakut family. Clinical symptoms of patients with dentatorubralpallidoluysian atrophy (DRPLA), a rare form of autosomal dominant spinocerebellar ataxia, from the Yakut family - ataxia, extrapyramidal and psychiatric disorders - it can be attributed to a later debut with a small degree of expansion of CAG repeats.
Дентаторубропаллидолюисовая атрофия в выборке неидентифицированных спиноцеребеллярных атаксий в Якутии / М. А. Варламова, И. А. Николаева Е. Е. Гуринова, А. Л. Сухомясова, А. Н. Ноговицына, Н. Р. Максимова // Якутский медицинский журнал. – 2018. – N 1 (61). – C. 17-20.
Количество страниц: 4 с.
Parameters of sleep and excessive daytime sleepiness were studied in children aged 7-12 years living in the Arctic zone of Russia. No gender differences in daytime sleepiness were found. The delay in bedtime onset for most children is reported. Self-questionnaires revealed awakenings in the middle of the night in almost half of the children, and insomnia was mild or moderate in 43.3% of the examined children in the European North of Russia. We have shown that children’s age affects the level of daytime sleepiness. Consequently, older children must sleep more than younger ones to achieve the same level of alertness and cognitive ability. Thus, children compensate for lack of sleep during the next day via daytime nap.
Дневная сонливость и параметры сна детей Европейского Севера РФ / С. Н. Коломейчук, А. В. Морозов, Д. А. Петрашова, В. В. Пожарская, Е. Б. Стафеева, И. А. Виноградова, М. Б. Бочкарёв, Б. А. Тарасов // Якутский медицинский журнал. — 2019. — N 3 (67). — С. 94-96.
DOI: 10.25789/YMJ.2019.67.26
Количество страниц: 6 с.
The review presents examples of translation of genomic studies into practical medicine of two common in Europe hereditary diseases - autosomal recessive cystic fibrosis and autosomal dominant Huntington's Chorea. With the development of genetic technologies in the Republic Sakha (Yakutia), translational medicine is becoming a reality, it is necessary to outline the approaches and problems in this field of study on example of spinocerebellar ataxia type 1 and autosomal recessive deafness type 1A, frequent in the Republic
ДНК-диагностика в клинической практике применительно к трансляционной медицине / С. К. Кононова, Н. А. Барашков, В. Г. Пшенникова, О. Г. Сидорова, Т. К. Давыдова, С. И. Софронова, А. Н. Романова, Э. К. Хуснутдинова, С. А. Федорова // Якутский медицинский журнал. — 2019. — N 3 (67). — С. 50-55. — DOI:10.25789/YMJ.2019.67.14
DOI: 10.25789/YMJ.2019.67.14
Количество страниц: 6 с.
The purpose of research were the substantiation of the diagnosis and correction or change of treatment of children with the epileptic and not epileptic paroxysms, directed in St.-PbSPMA for refinement of the diagnosis, the form of an epilepsy and selection of adequate treatment. As a result of complex diagnostic study of sick children with conducting video-EEG of monitoring it is established, that more than a half of children had the diagnosis epileptic paroxysms. Correction of treatment made after refinement of the diagnosis. As a result on clinical data efficacy of treatment of children with an epilepsy has increased. We were noted martempering of cognitive functions at children with not epileptic paroxysms
Гузева, О. В. Значение комплексного клинико-электрофизиологического обследования в дифференциальной диагностике и обосновании лечения пароксизмальных расстройств сознания у детей / О. В. Гузева // Якутский медицинский журнал. – 2011. – N 2 (34). – С. 68-72.