Место работы автора, адрес/электронная почта: Якутский научный центр комплексных медицинских проблем ; 677010, г. Якутск, ш. Сергеляхское, 4 ; e-mail: davtk@rambler.ru ; http://mednauka.com
Ученая степень, ученое звание: канд. мед. наук
Область научных интересов: Нервные болезни
ID Автора: SPIN-код: 7625-9057, РИНЦ AuthorID: 851041
Количество страниц: 4 с.
In the article the literature data on MSA, the clinical features are studied and modern diagnostic criteria for this disease are provided. We introduce our own observations of the patients with various forms of MSA who underwent inpatient treatment at the Center for Neurodegenerative Diseases of the Yakutsk Scientific Center for Complex Medical Problems in 2019-2020. These clinical cases have been studied with the aim to draw attention of general practitioners and neurologists to the disease onset among elderly patients and to the syndrome of autonomic insufficiency, which may be the initial manifestation of MSA, since this rare disease has a rapidly progressive course and leads to mortaltiy. In turn, the early diagnosis of the disease contributes to timely correction of autonomic and motor disorders and ultimately increases quality and lifetime
Трудности диагностики мультисистемной атрофии на ранних стадиях (клинические наблюдения) / А. Е. Адамова, А. А. Таппахов, Т. К. Давыдова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 119-122
DOI: 10.25789/YMJ.2020.72.29
Количество страниц: 6 с.
The article presents the experience of the specialized medical center on the basis of the clinic of the Federal State Budgetary Scientific Institution of the Yakutsk Scientific Center for Complex Medical Problems for patients with neurodegenerative diseases. The aim of this work is to present an improved model for providing specialized care for patients with neurodegenerative diseases in the Republic of Sakha (Yakutia) and an example of consolidation of the federal medical research institution and the regional ministry of health. The materials in the work include the register of patients with SCA 1 and MND, reporting data of regional neurologists from 2016-2018, regulatory documents of the Ministry of Health of the Russian Federation and the Republic of Sakha (Yakutia). The clinical, comparative analysis and organizational modeling were used for the study. The result of the analysis was the opening of the Center for Neurodegenerative Diseases at the YSC KMP
Опыт создания специализированного центра медицинской помощи для больных с нейродегенеративными заболеваниями на базе клиники научного учреждения / Т. К. Давыдова, С. К. Кононова, О. Г. Сидорова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 53-57
DOI: 10.25789/YMJ.2020.72.14
Количество страниц: 8 с.
The article presents the results of a clinical and genetic study of a Yakut family with hereditary spastic paraplegia (HSP). Patients with clinically diagnosed HSP and healthy family members were studied. The disease is clinically characterized as a progressive spastic paraplegia of the lower extremities concomitant peripheral neuropathy in advanced case. The methods of exome sequencing of the entire genome, molecular modeling of dynamin-2 and experimental reproduction of key elements of the HSP pathogenesis have been applied. Genetic analysis revealed a novel missense c.2155C> T, p.R719W mutation in the highly conserved GTP-effector domain of the dynamin-2 gene (DNM2). In experiments on HeLa cells, it was shown that mutant dynamin-2 affected endocytosis process. In-silico modeling determined that the identified mutation is located in the DNM2 bundle-signaling element and potentially disrupts the assembly and functional properties of the protein. Testing of this mutation in other Yakut families with HSP showed a negative result, which once again confirms the genetic heterogeneity of this pathology
Аутосомно-доминантная спастическая параплегия в четырех поколениях якутской семьи, вызываемая мутацией в динамине-2 / Т. М. Сивцева, Л. Г. Гольдфарб, Т. К. Давыдова [и другие] // Якутский медицинский журнал. — 2020. — N 1 (69). — С. 6-12.
DOI: 10.25789/YMJ.2020.69.01
Количество страниц: 6 с.
Анализ деятельности кабинета когнитивных расстройств центра нейродегеративных заболеваний клиники Якутского научного центра комплексных медицинских проблем / Ю. И. Хабарова, З. Н. Алексеева, Т. К. Давыдова, О. В. Татаринова // Якутский медицинский журнал. — 2020. — N 3 (71). — С. 119-124. – DOI: 10.25789/YMJ.2020.71.30.
DOI: 10.25789/YMJ.2020.71.30
Количество страниц: 4 с.
A retrospective analysis of the data of patients with spinocerebellar ataxia type 1 who received supportive care at the Center for Neurodegenerative Diseases YSC CMP Hospital for the period from September 2017 to June 2019 was performed. Data on age, educational and marital status of patients are presented, and in particular, an analysis of the change in type of professional activity and family status associated with the period of pronounced manifestation of the SCAI clinic was carried out.
Медико-социальная характеристика пациентов со спиноцеребеллярной атаксией I типа, получивших поддерживающую терапию на базе ЦНДЗ ЯНЦ КМП / О. Г. Сидорова, С. К. Кононова, Т. К. Давыдова, С. И. Софронова, С. А. Федорова, Э. К. Хуснутдинова, В. Л. Ижевская // Якутский медицинский журнал. — 2019. — N 4 (68). — С. 129-131.
DOI: 10.25789/YMJ.2019.68.37
Количество страниц: 6 с.
The review presents examples of translation of genomic studies into practical medicine of two common in Europe hereditary diseases - autosomal recessive cystic fibrosis and autosomal dominant Huntington's Chorea. With the development of genetic technologies in the Republic Sakha (Yakutia), translational medicine is becoming a reality, it is necessary to outline the approaches and problems in this field of study on example of spinocerebellar ataxia type 1 and autosomal recessive deafness type 1A, frequent in the Republic
ДНК-диагностика в клинической практике применительно к трансляционной медицине / С. К. Кононова, Н. А. Барашков, В. Г. Пшенникова, О. Г. Сидорова, Т. К. Давыдова, С. И. Софронова, А. Н. Романова, Э. К. Хуснутдинова, С. А. Федорова // Якутский медицинский журнал. — 2019. — N 3 (67). — С. 50-55. — DOI:10.25789/YMJ.2019.67.14
DOI: 10.25789/YMJ.2019.67.14
Количество страниц: 4 с.
With the purpose to study the peculiarities of sporadic and family form of PMA during the period from 1986 to 2016 we performed а research that revealed a moderate rate of progression in patients with sporadic cases of PMA and a slow rate of progression in its family form. In the family form of the disease, an earlier age of debut was observed. In men, the disease began earlier than in women, compared with sporadic PMA patients.
Давыдова, Т. К. Сравнительный анализ спорадических случаев и семейной формы прогрессирующей мышечной атрофии за 30-летний период (1986-2016 гг.) в Республике Саха (Якутия) / Т. К. Давыдова, Т. Я. Николаева, Л. Т. Оконешникова // Якутский медицинский журнал. — 2018. — N 4 (64). — С. 110-113. — DOI: 10.25789/YMJ.2018.64.34.
DOI: 10.25789/YMJ.2018.64.34