Количество страниц: 4 с.
Боякова, С. И. Народы Арктики: механизмы адаптации к экстремальной природной среде / С. И. Боякова // Наука и образование. – 2001. – N 2 (22). – С. 74-77.
Количество страниц: 4 с.
Стоматологической службе Республики Саха (Якутия) – 100 лет / И. Д. Ушницкий, М. Ю. Пупелене, О. И. Ширко [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 131-134.
DOI: 10.25789/YMJ.2020.72.32
Количество страниц: 6 с.
A literature review of the disease spinocerebellar ataxia type 17 (SCA 17) was carried out. The clinical observation of SCA 17 was presented considering the absence of inverse correlation between a degree of expansion and age of manifestation of SCA 17 symptoms, as well as direct relationship between the degree of expansion of repeats and the severity of clinical manifestations. We also revealed differences in the clinical picture of SCA 17 in this case and SCA 1, which is widespread in Yakutia
Особенности течения спиноцеребеллярной атаксии 17-го типа в Якутии / М. А. Варламова, Т. К. Давыдова, П. С. Назарова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 125-130.
DOI: 10.25789/YMJ.2020.72.31
Количество страниц: 4 с.
The article presents a clinical case of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), which was diagnosed for the first time in a 27-year-old man with bronchial asthma, eosinophilia, and gastrointestinal tract involvement. A retrospective analysis of the disease demonstrates the difficulties in diagnosing this disease. In this clinical case, the diagnosis was made 1.5-2 years after the onset of the first manifestations of the disease, in the second period of the development of the disease, based on the symptoms of the disease that were identified in the patient: bronchial asthma, rhinosinusopathy, pulmonary infiltrates, hypereosinophilia, despite the absence of biological markers of vasculitis. This syndrome is infrequently in clinical practice; however, doctors of various specialties should be aware of identifying this syndrome in their patients
Асекритова, А. С. Клинический случай эозинофильного гранулематоза с полиангиитом: трудности диагностики и клиническая картина / А. С. Асекритова, Э. А. Емельянова, А. П. Далбараева // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 122-125.
DOI: 10.25789/YMJ.2020.72.30
Количество страниц: 4 с.
In the article the literature data on MSA, the clinical features are studied and modern diagnostic criteria for this disease are provided. We introduce our own observations of the patients with various forms of MSA who underwent inpatient treatment at the Center for Neurodegenerative Diseases of the Yakutsk Scientific Center for Complex Medical Problems in 2019-2020. These clinical cases have been studied with the aim to draw attention of general practitioners and neurologists to the disease onset among elderly patients and to the syndrome of autonomic insufficiency, which may be the initial manifestation of MSA, since this rare disease has a rapidly progressive course and leads to mortaltiy. In turn, the early diagnosis of the disease contributes to timely correction of autonomic and motor disorders and ultimately increases quality and lifetime
Трудности диагностики мультисистемной атрофии на ранних стадиях (клинические наблюдения) / А. Е. Адамова, А. А. Таппахов, Т. К. Давыдова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 119-122
DOI: 10.25789/YMJ.2020.72.29
Количество страниц: 4 с.
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Анатомия. Физиология,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Анатомия. Физиология.
The article presents the results of the analysis of the literature data on the molecular genetic mechanisms of control and regulation of circadian rhythms that determine the chronotype of a person. It has been established that disturbance of circadian rhythms arising as a result of psychoemotional and physical stress expressed in degree and / or duration, can lead to a decrease in the body's resistance to stress factors with the subsequent development of maladjustment processes, which in turn can be a trigger mechanism for the onset of the development of such pathological conditions as diseases of the cardiovascular system, gastrointestinal tract, autoimmune, mental, neurodegenerative, oncological and other diseases. According to the results of numerous studies, the molecular genetic control of circadian rhythms consists of interacting positive and negative feedbacks of regulatory loops of clock genes, such as genes Bmal1, Clock, Per1, Per2, Per3, TIM, Npas2, Cry1 and Cry2, Csnk1d, Csnk1e, Rev-erbα, Rora, Bhlhe40, Bhlhe41, as well as genes FBXL3, FTO, MADD, CYP2A6, ARNTL, Mel1a, Mel1b and GPR50. The transcription factors encoded by these genes, enzymes, transporters, prohormones, signaling and other proteins are involved in regulation of daily frequency. Despite the fact that the main components of the molecular genetic mechanisms of circadian rhythms are already known, the issue of regulating their work remains relevant today. The results of studies carried out on different populations with respect to individual polymorphic variants of genes are not always unambiguous and require a more detailed study, since it is the result of the interaction of genes that can determine their phenotypic effect. Thus, understanding the molecular mechanisms and identifying genetic markers that cause disturbances in circadian rhythms is an important step in the development of methods aimed at preventing and correcting pathological conditions caused by maladjustment processes
Соловьева, Н. А. Генетические аспекты регуляции циркадных ритмов, влияющих на устойчивость к стрессу / Н. А. Соловьева, О. Н. Колосова // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 112-115.
DOI: 10.25789/YMJ.2020.72.27
Количество страниц: 6 с.
- Математика. Естественные науки > Общая биология. Антропология. Вирусология. Микробиология,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Гинекология. Женские болезни. Акушерство,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Гинекология. Женские болезни. Акушерство,
- НАУКА ЯКУТИИ > МАТЕМАТИКА. ЕСТЕСТВЕННЫЕ НАУКИ > Общая биология. Антропология. Вирусология. Микробиология.
The analysis of cytological samples of 100 women aged 23 to 60 years was carried out by liquid-based cytology. The predominance of NILM in the samples in comparison with intraepithelial lesions of the cervix was noted. Among intraepithelial lesions, low-grade LSIL was significantly more common. Positive HPV tests were found in less than half of the cases in tested women. Among the positive tests of high oncogenic risk the types 16 and 51 were considered as high-risk HPV types. There is approximately equal positivity of the high-risk HPV test in women with NILM and intraepithelial lesions (LSIL, HSIL, ASCUS). The positivity of the high-risk HPV test depends on age: in women under 45 years this indicator is higher than in women 46 years and older. According to our survey, with cytological study it is necessary to apply integrated test approach when screening high-risk HPV infection. The combined use of liquid-based cytology and HPV testing can improve the effectiveness of diagnostics by reducing the amount of uninformative material and allows to detect pathological changes at an earlier stage. It will significantly increase the value of diagnostic measures and will improve cytologist’s experience in diagnosing and giving recommendations in clinical practice of cervical pathologies
Вирус папилломы человека как фактор развития рака шейки матки / М. П. Кириллина, И. В. Кононова, С. И. Софронова, П. М. Иванов // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 82-86
DOI: 10.25789/YMJ.2020.72.20
Количество страниц: 6 с.
A vacA gene is important virulence factor that encodes vacuolating toxin and presents in all strains of Helicobacter pylori. There is significant difference between strains in vacuolating activity determined by different sequences in the middle (m) and signal (s) regions. Helicobacter pylori vacAm has m1 and m2 alleles, vacAs has s1 and s2 alleles. The higher grade of cytotoxic activity shows Helicobacter pylori with vacAs1m1 strains than s1m2, while s2m2 has not produced vacuolating cytotoxin. The effect of vacA gene alleles on gastroduodenal diseases in patients of Yakutia earlier has not been studied. The aim of this work is an associative analysis of the clinical outcomes of the vacA Helicobacter pylori variant gene and its association with the course of gastroduodenal diseases among Yakuts. According to the results of the histological report, 154 patients (out of 322 examined) were included in the study, who had H. pylori in the antrum of the stomach. Patients were divided into two groups: chronic gastritis (n=65) and chronic gastritis with erosive and ulcerative lesions (n=89). The average age was 26,6 years. The diagnosis of chronic gastritis was established in 65 cases (42,2%), and chronic gastritis with erosive and ulcerative lesions was diagnosed in 89 cases (57,7%). A vacAs1m1 was found in 30 out of 39 patients with erosive and ulcerative lesions (76,9%) (p
Анализ клинических исходов у пациентов с гастродуоденальными заболеваниями в зависимости от вариантов гена vacA Helicobacter pylori в Якутии / Н. Н. Готовцев, Н. А. Барашков, Т. В. Борисова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 69-73
DOI: 10.25789/YMJ.2020.72.18
Количество страниц: 6 с.
- Общественные науки. Образование > Экономика. Экономические науки. Политическая экономия > Труд. Наука о труде. Экономика труда. Организация труда,
- Прикладные науки. Медицина. Ветеринария. Техника. Сельское хозяйство > Медицина > Патология. Клиническая медицина > Оториноларингология,
- НАУКА ЯКУТИИ > ОБЩЕСТВЕННЫЕ НАУКИ > Экономика. Экономические науки. Политическая экономия,
- НАУКА ЯКУТИИ > ПРИКЛАДНЫЕ НАУКИ. МЕДИЦИНА. ТЕХНИКА. СЕЛЬСКОЕ ХОЗЯЙСТВО > Медицина > Патология. Клиническая медицина > Оториноларингология.
We have studied the impact of harmful physical factors of production on the development of occupational sensorineural hearing loss (OSHL) among civil aviation flight personnel and technological transport drivers in the mining industry of Yakutia. It was found that among flight personnel, OSHL is the only diagnosis of an occupational disease, the severity of hearing loss depends on age, length of service, and the level of excessive noise (typical pattern of OSHL). In car drivers, OSHL is combined with other diagnoses caused by exposure to local and/or general vibration, the clinical course is more severe, with a predominance of II and III degrees
Физические факторы риска при профессиональной нейросенсорной тугоухости / Ф. М. Терютин, В. Г. Пшенникова, Н. А. Барашков [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 65-69
DOI: 10.25789/YMJ.2020.72.17
Количество страниц: 6 с.
This article presents the comparative characteristics of the dynamics of indicators of physical development of young men. The study aims to carry out a comparative analysis of the dynamics of morphological and functional indicators of physical development and the functional state of male bodies at the youthful stage of ontogenesis. We have analyzed the results of the one-time study (1999 and 2019) of 1st-year students; in total, 760 young male students were examined in 1999, and 273 students in 2019 (aged 17-18). To reveal research results of physical development indicators, we have carried out a comprehensive study of somatoscopic, somatometric, and functional indicators of young men. Analysis of the morphological and functional indicators of men in Yakutia at the youthful stage of ontogenesis over time (20 years of difference). We take into account the individual typological characteristics of the organism, manifested at the structural and functional level (somatotype), and reflected in the main anatomical and anthropological indicators of the organism. This makes it possible to state the impact of external factors (environmental, social influences; a complex of genetic and cultural characteristics) on the indigenous people of the North
Сравнительная характеристика динамики морфофункциональных показателей физического развития мужчин молодого возраста / Д. К. Гармаева, С. П. Винокурова, Л. И. Аржакова [и другие] // Якутский медицинский журнал. — 2020. — N 4 (72). — С. 61-65
DOI: 10.25789/YMJ.2020.72.16